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Here's everything research has to say on Syphilis in 2023

Most cited journal articles published in 2022 on Syphilis

Syphilis is a sexually transmitted infection (STI) caused by the bacteria Treponema pallidum. It is characterized by a variety of symptoms, including a painless sore or rash, fever, swollen lymph nodes, and flu-like symptoms. If left untreated, syphilis can progress through different stages, causing serious complications such as damage to the nervous system, heart, and brain.

Research has shown that syphilis is a significant public health problem, with an estimated 10.6 million new cases of the disease reported globally in 2019. The infection is more prevalent in certain populations, such as men who have sex with men, sex workers, and people living with HIV.

Syphilis can be treated with antibiotics such as penicillin, but it is important to diagnose the disease as early as possible to prevent serious complications.

Research has also focused on understanding the epidemiology and risk factors for syphilis, as well as the genetics and evolution of the T. pallidum bacteria.

Prevention of syphilis mainly focused on promoting safe sexual practices such as using condoms and getting tested for STIs regularly.

Research is ongoing to develop new treatments and diagnostic methods for syphilis, as well as to understand the neural and behavioral effects of the disease.

In addition, research is ongoing to understand the complex interactions between syphilis and HIV, as people with syphilis are at greater risk of contracting HIV, and conversely, people with HIV are at greater risk of developing severe syphilis.

DOI: 10.1002/jmv.27931
2022
Cited 84 times
Epidemiological trends and clinical features of the ongoing monkeypox epidemic: A preliminary pooled data analysis and literature review
Nicola Luigi Bragazzi, Jude Dzevela Kong, Naim Mahroum, Christina Tsigalou, Rola Khamisy‐Farah, Manlio Converti, Jianhong Wu
Outbreak
Epidemiology
Medicine
DOI: 10.1016/j.tmaid.2022.102368
2022
Cited 42 times
Coinfection of syphilis and monkeypox in HIV positive man in Prague, Czech Republic
Beatrice Bížová, Dan Veselý, Milan Trojánek, Filip Rob
Coinfection
Czech
Virology
DOI: 10.1001/jama.2021.23487
2022
Cited 21 times
Diagnosis and Treatment of Sexually Transmitted Infections
Susan Tuddenham, Matthew M Hamill, Khalil G Ghanem
Gonorrhea
Medicine
Syphilis
DOI: 10.3390/pharmaceutics14061283
2022
Cited 12 times
A Historical Review of Brain Drug Delivery
William M. Pardridge
Drug delivery
Blood–brain barrier
Drug delivery to the brain
DOI: 10.1186/s12911-022-01773-1
2022
Cited 12 times
Stochastic Petri net model describing the relationship between reported maternal and congenital syphilis cases in Brazil
Ricardo A M Valentim, Gleyson J P Caldeira-Silva, Rodrigo D da Silva, Gabriela A Albuquerque, Ion G M de Andrade, Ana Isabela L Sales-Moioli, Talita K de B Pinto, Angélica Espinosa Miranda, Leonardo J Galvão-Lima, Agnaldo S Cruz, Daniele Montenegro da Silva Barros, Anna Giselle C D R Rodrigues
Syphilis
Logistic regression
Medicine
DOI: 10.3389/fimmu.2022.857727
2022
Cited 11 times
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner
Zhijia Li, Muzhou Teng, Yinbo Jiang, Litian Zhang, Xi Luo, Yuhui Liao, Bin Yang
SOCS3
Inflammation
Downregulation and upregulation
DOI: 10.1016/j.vaccine.2021.11.010
2022
Cited 11 times
Moving the needle on racial disparity: COVID-19 vaccine trust and hesitancy
Cheryl Lin, Pikuei Tu, Thomas C. Terry
Distrust
Vaccination
Pandemic
DOI: 10.1016/j.lana.2021.100163
2022
Cited 10 times
Use of Interrupted Time Series Analysis in Understanding the Course of the Congenital Syphilis Epidemic in Brazil
Rafael Z. Pinto, Ricardo Alexsandro de Medeiros Valentim, Lyrene Fernandes da Silva, Gustavo Fontoura de Souza, Thaísa Góis Farias de Moura Santos Lima, Carlos Augusto Fernandes de Oliveira, Marquiony Marques dos Santos, Angélica Espinosa Miranda, Aliete Cunha-Oliveira, Vivekanandan Kumar, Rifat Atun
Congenital syphilis
Syphilis
Context (archaeology)
DOI: 10.1016/s1473-3099(22)00222-5
2022
Cited 10 times
Safety and immunogenicity of VPM1002 versus BCG in South African newborn babies: a randomised, phase 2 non-inferiority double-blind controlled trial
Mark F Cotton, Shabir A Madhi, Angelique K Luabeya, Michele Tameris, Anneke C Hesseling, Justin Shenje, Elisma Schoeman, Mark Hatherill, Sajjad Desai, Dhananjay Kapse, Sina Brückner, Anthonet Koen, Lisa Jose, Andrew Moultrie, Sutika Bhikha, Gerhard Walzl, Andrea Gutschmidt, Leigh A Kotze, Devon L Allies, Andre G Loxton, Umesh Shaligram, Maria Abraham, Hilary Johnstone, Leander Grode, S H E Kaufmann, Prasad S Kulkarni
Medicine
Tuberculosis
Pediatrics
DOI: 10.1093/cid/ciab287
2022
Cited 9 times
Previous Syphilis Alters the Course of Subsequent Episodes of Syphilis
Christina M. Marra, Clare L. Maxwell, Sharon K. Sahi, Lauren C. Tantalo, Shelia B. Dunaway, Sheila A. Lukehart
Syphilis
Medicine
Neurosyphilis
DOI: 10.1016/j.survophthal.2021.06.003
2022
Cited 9 times
Ocular syphilis
João M. Furtado, Milena Simões, Daniel Vitor Vasconcelos-Santos, Genevieve F. Oliver, Mudit Tyagi, Heloisa Nascimento, David L. Gordon, Justine R. Smith
Syphilis
Medicine
Uveitis
DOI: 10.1016/j.ajoc.2022.101532
2022
Cited 7 times
Multiple evanescent white dot syndrome following BNT162b2 mRNA COVID-19 vaccination
Eriko Yasuda, Wataru Matsumiya, Maeda Yoshifumi, Sentaro Kusuhara, Quan Dong Nguyen, Makoto Nakamura, Rumiko Hara
Medicine
Ophthalmology
Fluorescein angiography
DOI: 10.1111/bjd.21847
2022
Cited 7 times
A monkeypox virus infection mimicking primary syphilis
Martina Turco, Fabrizio R Mancuso, Luigi Pisano
Monkeypox
Outbreak
Syphilis
DOI: 10.1111/add.15666
2022
Cited 7 times
Increase in recreational drug use between 2008 and 2018: results from a prospective cohort study among HIV‐negative men who have sex with men
Liza Coyer, Anders Boyd, Udi Davidovich, Ward P H van Bilsen, Maria Prins, Amy Matser
Medicine
Gee
Men who have sex with men
DOI: 10.3389/fpubh.2022.855680
2022
Cited 6 times
The Text Mining Technique Applied to the Analysis of Health Interventions to Combat Congenital Syphilis in Brazil: The Case of the “Syphilis No!” Project
Marcella Silva da Rocha, Marquiony Marques dos Santos, Raphael Silva Fontes, Andréa Santos Pinheiro de Melo, Aliete Cunha-Oliveira, Angélica Espinosa Miranda, Carlos Augusto Fernandes de Oliveira, Hugo Gonçalo Oliveira, Cristine Gusmão, Thaísa Capato Lima, Rafael Z. Pinto, Daniele Porto Barros, Ricardo Alexsandro de Medeiros Valentim
Syphilis
Psychological intervention
Health care
DOI: 10.1007/s10654-021-00809-6
2022
Cited 6 times
Non-therapeutic male circumcision in infancy or childhood and risk of human immunodeficiency virus and other sexually transmitted infections: national cohort study in Denmark
Morten Frisch
Medicine
Cohort
Syphilis
DOI: 10.1128/msphere.00009-22
2022
Cited 6 times
Selective Whole-Genome Amplification as a Tool to Enrich Specimens with Low Treponema pallidum Genomic DNA Copies for Whole-Genome Sequencing
Charles M. Thurlow, Sandeep J. Joseph, Lilia Ganova-Raeva, Samantha S. Katz, Lara Pereira, Cheng Chen, Alyssa Debra, Kendra Vilfort, Kimberly Workowski, Stephanie E. Cohen, Hilary Reno, Yongcheng Sun, Mark Burroughs, Mili Sheth, Kai-Hua Chi, Damien Danavall, Susan S. Philip, Weiping Cao, Ellen N. Kersh, Allan Pillay
Treponema
Biology
Multiple displacement amplification
DOI: 10.1016/s2666-5247(22)00035-0
2022
Cited 6 times
Characterisation of Treponema pallidum lineages within the contemporary syphilis outbreak in Australia: a genomic epidemiological analysis
M. Taouk, George Taiaroa, Shivani Pasricha, Sophie Herman, Eric P F Chow, Francesca Azzatto, Bowen Zhang, Cheryll Sia, Sebastián Duchêne, Alvin Lee, Nasra Higgins, Jacqueline Prestedge, Yi Chao Lee, Nicholas R. Thomson, Bianca Graves, Ella M. Meumann, Manoji Gunathilake, Jane S Hocking, Catriona S. Bradshaw, Mathew A. Beale, Benjamin P Howden, Marcus Y Chen, Christopher K Fairley, Danielle J. Ingle, Deborah A Williamson
Treponema
Biology
Lineage (genetic)
DOI: 10.1097/icb.0000000000000912
2022
Cited 6 times
MULTIMODAL IMAGING AND TREATMENT OF SYPHILITIC CHOROIDAL NEOVASCULARIZATION
Chiara Giuffrè, Alessandro Marchese, Maria Vittoria Cicinelli, Elisabetta Miserocchi, Giuseppe Querques, Francesco Bandello, Giulio Modorati
Medicine
Choroidal neovascularization
Chorioretinitis
DOI: 10.3389/fmed.2022.812016
2022
Cited 5 times
HTLV-1 and Co-infections
Carolina Rosadas, Graham P. Taylor
Immunology
Virology
Strongyloides stercoralis
DOI: 10.1136/sextrans-2020-054911
2022
Cited 5 times
Syphilis self-testing to expand test uptake among men who have sex with men: a theoretically informed mixed methods study in Zimbabwe
Clarisse Sri-Pathmanathan, Definate Nhamo, Takudzwa Mamvuto, Gwendoline Chapwanya, Fern Terris-Prestholt, Imelda Mahaka, Michael Marks, Joseph D. Tucker
Syphilis
Men who have sex with men
Medicine
DOI: 10.1371/journal.pmed.1003930
2022
Cited 5 times
Expanding syphilis test uptake using rapid dual self-testing for syphilis and HIV among men who have sex with men in China: A multiarm randomized controlled trial
Cheng Wang, Jason J. Ong, Peizhen Zhao, Ann Marie Weideman, Weiming Tang, M. N. K. Smith, Michael Marks, Hongyun Fu, Weibin Cheng, Fern Terris-Prestholt, Heping Zheng, Joseph D. Tucker, Bin Yang
Syphilis
Men who have sex with men
Medicine
DOI: 10.1016/j.drugalcdep.2022.109320
2022
Cited 5 times
Frequency of reported methamphetamine use linked to prevalence of clinical conditions, sexual risk behaviors, and social adversity in diverse men who have sex with men in Los Angeles
Steven Shoptaw, Michael Li, Marjan Javanbakht, Amy Ragsdale, David Goodman-Meza, Pamina M. Gorbach
Men who have sex with men
Serostatus
Medicine
DOI: 10.23736/s2724-606x.21.04870-3
2022
Cited 5 times
The negative impact of most relevant infections on fertility and assisted reproduction technology
Luigi Carbone, Carlo Alviggi, Antonio La Marca, Federica Cariati, Roberta Vallone, Antonio Raffone, Cira Buonfantino, Michela Palese, Marika Mascia, Raffaella Di Girolamo, Martina Capuzzo, Sandro C. Esteves
Infertility
Fertility
Pelvic inflammatory disease
DOI: 10.1164/rccm.202201-0136so
2022
Cited 4 times
Fiftieth Anniversary of Uncovering the Tuskegee Syphilis Study: The Story and Timeless Lessons
Martin J. Tobin
Bioethics
Medicine
Syphilis