ϟ

Here's what research has to say about medullary thyroid cancer (MTC) in 2023

Most cited journal articles published in 2022 on the topic of medullary thyroid cancer (MTC)

Medullary thyroid cancer (MTC) is a type of thyroid cancer that arises from the C cells of the thyroid, which produce the hormone calcitonin. It accounts for about 3-10% of all thyroid cancers. MTC can be inherited in some cases and can be associated with inherited syndromes such as multiple endocrine neoplasia type 2 (MEN 2). Symptoms of MTC may include a lump in the neck, hoarseness, difficulty swallowing, and in advanced cases, metastasis to lymph nodes or other organs. The treatment of MTC typically involves surgery to remove the thyroid gland, as well as post-operative radioactive iodine therapy and/or targeted therapy with drugs such as vandetanib or cabozantinib.

DOI: 10.1200/jco.21.01329

International Medullary Thyroid Carcinoma Grading System: A Validated Grading System for Medullary Thyroid Carcinoma

Bin Xu, Talia L Fuchs, Sara Ahmadi, Mohammed A. Alghamdi, Bayan Alzumaili, Mohamed Amine Bani, Eric Baudin, Angela Chou, Antonio Leo, James A. Fagin, Ian Ganly, Anthony Glover, Dana M. Hartl, Christina Kanaan, Pierre Khneisser, Fedaa Najdawi, Aradhya Nigam, Alexander J Papachristos, Andrea Repaci, Philip M. Spanheimer, Erica Solaroli, Brian R. Untch, Justine A. Barletta, Giovanni Tallini, Abir Al Ghuzlan, Anthony J. Gill, Ronald Ghossein

Grading (engineering)

Medullary thyroid cancer

DOI: 10.1016/j.annonc.2022.04.009

ESMO Clinical Practice Guideline update on the use of systemic therapy in advanced thyroid cancer

Sebastiano Filetti, Cosimo Durante, Dominik Hartl, Sophie Leboulleux, Laura D. Locati, Katie L. Newbold, Mauro Papotti, Alfredo Berruti

DOI: 10.1089/thy.2021.0542

Clinical Application of Next-Generation Sequencing in Advanced Thyroid Cancers

Lucy X Ma, Osvaldo Espin-Garcia, Philippe Lucien Bedard, Tracy L Stockley, Rebecca Prince, Ozgur Mete, Monika Krzyzanowska

Medullary thyroid cancer

DOI: 10.1210/clinem/dgac325

Somatic <i>RET</i> Indels in Sporadic Medullary Thyroid Cancer: Prevalence and Response to Selpercatinib

Rossella Elisei, Raffaele Ciampi, Antonio Matrone, Alessandro Prete, Carla Gambale, Teresa Ramone, George Simeakis, Gabriele Materazzi, Liborio Torregrossa, Clara Ugolini, Cristina Romei

Internal medicine

DOI: 10.3390/cancers14030724

CONUT Score: A New Tool for Predicting Prognosis in Patients with Advanced Thyroid Cancer Treated with TKI

Cristina Dalmiglio, Lucia Brilli, Michele Campanile, Cristina Ciuoli, Alessandra Cartocci, Maria Grazia Castagna

Internal medicine

DOI: 10.1002/hed.26987

The differences in distant metastatic patterns and their corresponding survival between thyroid cancer subtypes

Huy Gia Vuong, Minh-Khang Le, Lewis A. Hassell, Tetsuo Kondo, Kennichi Kakudo

Thyroid carcinoma

DOI: 10.1186/s12967-022-03511-7

Identification of functional pathways and molecular signatures in neuroendocrine neoplasms by multi-omics analysis

Viola Melone, Annamaria Salvati, Domenico Palumbo, Giorgio Giurato, Giovanni Nassa, Francesca Rizzo, Luigi Palo, Alessandro Giordano, Mariarosaria Incoronato, Mario Vitale, Caterina Mian, Immacolata Di Biase, Stefano Cristiano, Viviana Narciso, Monica Cantile, Annabella Di Mauro, Fabiana Tatangelo, Salvatore Tafuto, Roberta Modica, Claudia Pivonello, Marco Salvatore, Annamaria Colao, Alessandro Weisz, Roberta Tarallo

Computational biology

DOI: 10.1080/17460441.2022.1995351

Discovery, preclinical development, and clinical application of pralsetinib in the treatment of thyroid cancer

Pietro Locantore, Roberto Novizio, Andrea Corsello, Rosa Maria Paragliola, Alfredo Pontecorvi, Salvatore Maria Corsello

Medullary thyroid cancer

DOI: 10.1210/clinem/dgac337

Selpercatinib Treatment of <i>RET</i>-Mutated Thyroid Cancers Is Associated With Gastrointestinal Adverse Effects

Venessa Tsang, Anthony Gill, Matti Gild, Brett Lurie, Lucy Blumer, Rhonda Siddall, Roderick Clifton-Bligh, Bruce Robinson

Medullary thyroid cancer

DOI: 10.1210/clinem/dgac352

A Novel Germline Deletion of p.C630 in <i>RET</i> Causes MTC and Promotes Cell Proliferation and Sensitivity to Pralsetinib

Xiao Ma, Xiuli Ma, Lihan Chin, Zhen Zhu, Haibo Han

MAPK/ERK pathway

Molecular biology

DOI: 10.1016/j.surg.2021.07.035

Abandoning node dissection for desmoplasia-negative encapsulated unifocal sporadic medullary thyroid cancer

Andreas Machens, Peter Kaatzsch, Kerstin Lorenz, Lars-Christian Horn, Claudia Wickenhauser, Kurt Werner Schmid, Henning Dralle, Udo Siebolts

Medullary thyroid cancer

DOI: 10.1530/erc-21-0368

Metastatic medullary thyroid carcinoma: a new way forward

Anna Angelousi, Aimee R Hayes, Eleftherios Chatzellis, Gregory A Kaltsas, Ashley B Grossman

DOI: 10.3389/fendo.2022.896287

Peptide Receptor Radionuclide Therapy in Thyroid Cancer

Sriram Gubbi, Christian Koch, Joanna Klubo-Gwiezdzinska

Radionuclide therapy

PMID: https://pubmed.ncbi.nlm.nih.gov/35411240

Emerging role of competing endogenous RNA and associated noncoding RNAs in thyroid cancer.

Qian Bai, Zhen-jie Pan, Ghulam Nabi, Farooq Rashid, Yang Liu, Suliman Khan

Competing endogenous RNA

DOI: 10.1016/j.jpedsurg.2021.08.008

Pediatric solid tumors and associated cancer predisposition syndromes: Workup, management, and surveillance. A summary from the APSA Cancer Committee

Christa N. Grant, Daniel S. Rhee, Elisabeth T. Tracy, Jennifer H. Aldrink, Reto M. Baertschiger, Timothy B. Lautz, Richard D. Glick, David A. Rodeberg, Peter F. Ehrlich, Emily R. Christison-Lagay

Pediatric cancer

DOI: 10.3389/fendo.2022.860671

Target Therapy in Thyroid Cancer: Current Challenge in Clinical Use of Tyrosine Kinase Inhibitors and Management of Side Effects

Ivana Puliafito, Francesca Esposito, Angela Prestifilippo, Stefania Marchisotta, Dorotea Sciacca, Maria Prosperina Vitale, Dario Giuffrida

Anaplastic thyroid cancer

Medullary thyroid cancer

DOI: 10.1038/s41598-022-12590-x

Gas chromatography-mass spectrometry-based untargeted metabolomics reveals metabolic perturbations in medullary thyroid carcinoma

Morteza Ghaffari Jajin, Raziyeh Abooshahab, Kourosh Hooshmand, Ali Moradi, Seyed Davar Siadat, Roghieh Mirzazadeh, Koorosh Goodarzvand Chegini, Fereidoun Azizi

Thyroid carcinoma

Metabolic pathway

DOI: 10.1530/erc-21-0414

Translating the immune microenvironment of thyroid cancer into clinical practice

Lucas Leite Cunha, Laura Sterian Ward

Tumor microenvironment

DOI: 10.3390/cancers14081951

Medullary Thyroid Carcinoma Mutational Spectrum Update and Signaling-Type Inference by Transcriptional Profiles: Literature Meta-Analysis and Study of Tumor Samples

Emanuela Minna, Paola Romeo, Matteo Dugo, Loris De Cecco, Antonella Aiello, Federico Pistore, Andrea Carenzo, Angela Greco, Maria Grazia Borrello

Thyroid carcinoma

DOI: 10.3390/cancers14051272

Molecular Imaging and Theragnostics of Thyroid Cancers

Luca Giovanella, Désirée Deandreis, Alexis Vrachims, Alfredo Campennì, Petra Petranović Ovčariček

Molecular imaging

DOI: 10.3389/fendo.2022.929091

What is the status of immunotherapy in thyroid neoplasms?

Alejandro Garcia-Alvarez, Jorge Hernando, Ana Carmona-Alonso, Jaume Capdevila

Anaplastic thyroid cancer

DOI: 10.1186/s13044-021-00119-9

Diagnostic characteristics, treatment patterns, and clinical outcomes for patients with advanced/metastatic medullary thyroid cancer

Rohan Parikh, Lisa M. Hess, Elizabeth Esterberg, Naleen Raj Bhandari, James A. Kaye

Medullary thyroid cancer

DOI: 10.1245/s10434-021-11158-9

Evaluation of Survival and Postoperative Radiation Among Patients with Advanced Medullary Thyroid Carcinoma: An Analysis of the National Cancer Database

Thomas J. Ow, Vikas Mehta, Seokhwa Kim, Mayand Vakil, Patricia Friedmann, Haejin In

Propensity score matching

DOI: 10.1530/erc-21-0258

The GIP/GIPR axis in medullary thyroid cancer: clinical and molecular findings

Daniela Regazzo, Loris Bertazza, Eva Galletta, Susi Barollo, Alberto Mondin, Stefania Zovato, Maurizio Iacobone, Eleonora Zilio, Carla Scaroni, Claudia M. Radu, Giulietta di Benedetto, Caterina Mian, Konstantinos Lefkimmiatis, Gianluca Occhi

Internal medicine

Medullary thyroid cancer

DOI: 10.3389/fendo.2022.829103

Susceptibility Genes and Chromosomal Regions Associated With Non-Syndromic Familial Non-Medullary Thyroid Carcinoma: Some Pathogenetic and Diagnostic Keys

María Sánchez-Ares, Soledad Cameselle-García, Ihab Abdulkader-Nallib, Gemma Rodríguez-Carnero, Carolina Beiras-Sarasquete, Jose A Puñal-Rodríguez, José Cameselle-Teijeiro

Thyroid carcinoma

Medullary carcinoma